Although bone cancer does not have a clearly defined cause, researchers identified several factors that increase the likelihood of developing these tumors.
Osteosarcoma most often occurs in people taking high doses of external beam radiation or treatment with certain anticancer drugs, children seem to be particularly sensitive.
A small number of bone cancers are hereditary. For example, children with hereditary retinoblastoma (a rare cancer of the eye) are at increased risk of developing osteosarcoma, particularly if treated with radiotherapy. In addition, people with hereditary defects of bones and people with metal implants, which doctors sometimes used to repair fractures, are more likely to develop osteosarcoma.Ewing's sarcoma is strongly associated with hereditary cancer syndromes, congenital, childhood or previous radiation exposure .
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